Second marriage

Mandela's second wife, Winnie Madikizela-Mandela, also came from the Transkei area, although they, too, met in Johannesburg, where she was the city's first black social worker. They had two daughters, Zenani (Zeni), born 4 February 1958, and Zindziswa (Zindzi), born 1960. Later, Winnie would be deeply torn by family discord which mirrored the country's political strife; while her husband was serving a life sentence on the Robben Island prison, her father became the agriculture minister in the Transkei. The marriage ended in separation (April 1992) and divorce (March 1996), fuelled by political estrangement.

Mandela still languished in prison when his daughter Zenani was married to Prince Thumbumuzi Dlamini in 1973, elder brother of King Mswati III of Swaziland. As a member by marriage of a reigning foreign dynasty, she was able to visit her father during his South African imprisonment while other family members were denied access. The Dlamini couple live and run a business in Boston. One of their sons, Prince Cedza Dlamini (born 1976), educated in the United States, has followed in his grandfather's footsteps as an international advocate for human rights and humanitarian aid. Thumbumuzi and Mswati's sister, Princess Mantfombi Dlamini, is the chief consort to King Goodwill Zwelithini of KwaZulu-Natal, who "reigns but does not rule" over South Africa's largest ethnic group under the auspices of South Africa's government. One of Queen Mantfombi's sons is expected to eventually succeed Goodwill as monarch of the Zulus, whose Inkatha Party leader, Mangosuthu Buthelezi, was one of the political rivals of Mandela, before and during his presidency.